A Journey Through Time
Most plant-based products developed to date have been formulated through a combination of botanical extracts and various excipients; however, their potential to reach biological targets has remained limited.
One of the main reasons for this limitation is that plant particles with an average diameter of 1500–2000 nanometers do not demonstrate sufficient efficacy in terms of cellular uptake and cannot cross the blood-brain barrier. After more than four years of R&D, AYE Exocure scientists have, for the first time in the world, succeeded in producing structures that are:
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Plant-based
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Smaller than 200 nanometers in size
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Orally administrable
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Stable for two years at room temperature
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Free from chemicals
These structures are intended to be taken up more efficiently by cells and to reach target areas that are inaccessible through conventional methods. In this way, the aim is for plant-based supplements to achieve a level that may help support biological systems.
AYE Exocure Advanced Manufacturing Technology
At the core of AYE Exocure’s R&D vision lies AYE Exocure Advanced Manufacturing Technology, which is based on transforming plant-derived extracts into particles below 200 nanometers through advanced purification and size-reduction processes. These particles retain their natural structures, are evaluated for biological compatibility, and possess a double-layer lipid membrane structure.
Through this technology, the components within plant extracts are not only reduced in size but are also:
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Stabilized in a way that may help them cross the blood-brain barrier,
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Enabled to interact with target areas without the need for carrier systems,
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Supported in their compatibility with biological processes at the cellular level,
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Expanded in their safe use potential through their natural and additive-free composition.
These advanced structures may also contribute to supporting intercellular communication in a manner similar to the body’s natural carrier systems. Findings in the scientific literature indicate that such structures may help maintain balance in biological processes such as oxidative stress and support renewal mechanisms.
Traditional botanical extracts can face limitations such as degradation in the digestive system, restricted absorption, and reduced biological interaction. AYE Exocure Advanced Manufacturing Technology may help overcome these limitations by:
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Supporting the effectiveness of components even at lower doses,
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Contributing to an earlier onset of interaction,
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Helping to enhance biological availability.
In all AYE Exocure formulations, this technology represents not only a production model but also a product of scientific responsibility and innovation that respects nature.
Toxicology Studies
At AYE Exocure, our priority in developing formulations is not only functional support but also achieving a high level of toxicological safety. In this context, toxicological evaluations for all our products have been carried out in line with the criteria of EFSA (European Food Safety Authority).
To date, the ingredients Coffea arabica, Panax ginseng, and Ginkgo biloba have been scientifically evaluated in collaboration with Istinye University under the leadership of Prof. Dr. Semra Sardaş, the Turkey Representative of the European Society of Toxicology. Comprehensive examinations revealed no toxic effects associated with these botanical ingredients, and the safe use potential of the formulation was demonstrated through scientific reports.
In addition, toxicity tests conducted in accordance with EMA and FDA standards at Kobay Experimental Animal Laboratory Inc. also revealed no adverse findings.
These results not only support the reliability of the current formulation on an international scale but also highlight the potential of AYE Exocure Advanced Manufacturing Technology to be evaluated in new areas with different botanical ingredients.
Scientific Studies and
International Recognition
In 2024, our scientific research examining the physicochemical structure of our formulations was accepted to the PubScholars International Neurology Congress, recognized as one of the world’s leading scientific gatherings in the field of neurology.
Conducted at Hacettepe University, this study thoroughly evaluated the stability profile, zeta potential, and UV/Vis spectra of plant-derived nanoparticles. The findings provided significant insights into the stability of these structures under environmental conditions and their potential for interaction with biological systems.
Approved after a rigorous review by the scientific committee, this study once again demonstrated that our work is considered noteworthy by the international scientific community—not only at the level of ingredients but also in its structural and technological aspects.
In 2025, our multi-center preclinical study was accepted to AD/PD 2025 – International Conference on Alzheimer’s, Parkinson’s and Other Neurodegenerative Diseases, held in Vienna and regarded as one of the most prestigious scientific events in the field.
This comprehensive study, conducted using cell culture models, animal experiments, and observational human data, evaluated critical markers such as cell viability, specific biomarker levels, oxidative stress parameters, and Amyloid Beta accumulation in detail.
Reviewed and approved by the scientific committee, the study was included in the program as a poster presentation. This recognition highlights that our formulation is not only composed of innovative components but also supported by robust experimental data and a strong scientific foundation acknowledged at the international level.